Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation
Summary: Mechanistic or mammalian target of rapamycin complex 1 (mTORC1) is an important regulator of effector functions, proliferation, and cellular metabolism in macrophages.The biochemical processes that are controlled by mTORC1 are still being defined.Here, we demonstrate that integrative multiomics in conjunction with a data-driven inverse mod